Pyrimidine derivatives useful as inhibitors of pkc-theta

Details Pyrimidine derivatives useful as inhibitors of pkc-theta Pyrimidine derivatives useful as inhibitors of pkc-theta

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 37/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2633992

Disclosed are novel compounds of formula (I) wherein R1, R2, R3, R4 and A are as defined herein, which are useful as inhibitors of PKC-theta and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of PKC-theta, includ-ing immunological disorders and type II diabetes. This invention also relates to pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

L'invention concerne de nouveaux composés de formule (I) dans laquelle R<SUP>1</SUP>, R<SUP>2</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP> et A sont tels que définis dans la présente, lesquels sont utiles comme inhibiteurs de la PKC-thêta et sont donc utiles pour traiter un grand nombre de maladies et de troubles qui sont facilités ou entretenus par l'activité de la PKC-thêta, dont des troubles immunologiques et le diabète de type II. L'invention concerne également des compositions pharmaceutiques comprenant ces composés, des procédés d'utilisation de ces composés dans le traitement de différentes maladies et de différents troubles, des procédés servant à préparer ces composés et des intermédiaires utiles dans ces procédés.

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