C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/218, 260/258
C07D 239/46 (2006.01) A61K 31/505 (2006.01) C07D 239/54 (2006.01) C07D 239/56 (2006.01) C07D 239/58 (2006.01) C07D 239/60 (2006.01)
Patent
CA 2039039
The invention is a pyrimidine nucleoside derivative represented by the following formula (I): Image wherein R1 represents ethyl group or isopropyl group; R2 and R3 independently represent hydrogen atom, an C1-C3 alkyl group or chlorine atom; X represents oxygen atom or sulfur atom; and Z represents sulfur atom or methylene group; with the proviso that R2 and R3 do not simultaneously represent hydrogen atoms when X represents oxygen atom and Z represents sulfur atom, or a pharmaceutically acceptable salt thereof. The pyrimidine nucleoside derivative and pharmaceutically acceptable salt thereof show a markedly higher anti-retroviral activity than conventional analogous compounds and have a relatively low toxicity against the host cells, and therefore, are useful as an active ingredient of antiviral agent.
Baba Masanori
de Clercq Erik Desire Alice
Miyasaka Tadashi
Tanaka Hiromichi
Ubasawa Masaru
Baba Masanori
de Clercq Erik Desire Alice
Mitsubishi Chemical Corporation
Miyasaka Tadashi
Ridout & Maybee Llp
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