Pyrimidine substituted purine derivatives

Details Pyrimidine substituted purine derivatives Pyrimidine substituted purine derivatives

C - Chemistry, Metallurgy

07

D

C07D 473/32 (2006.01) A61K 31/52 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2701581

The present invention relates to purine compounds that are useful as kinase Inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative conditions or disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative conditions or disorders including tumours and cancers as well as other disorders or conditions related to or associated with PI3 and/or mTOR kinases. Formula (I).

La présente invention concerne des composés de purine qui sont utilisés en tant qu'inhibteurs de la kinase. Plus spécifiquement, cette invention a pour objet des composés de purine, leurs procédés de préparation, des compositions pharmaceutiques les contenant et des utilisations de ces composés dans le traitement d'états ou de troubles prolifératifs. Ces composés peuvent être utilisés en tant que médicaments dans le traitement d'un certain nombre d'états ou de troubles prolifératifs, y compris des tumeurs et des cancers ainsi que d'autres états ou troubles apparentés ou associés à des kinases mTOR et/ou PI3. Formule (I).

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