Pyrimidine-thioalkyl and alkylether compounds

Details Pyrimidine-thioalkyl and alkylether compounds Pyrimidine-thioalkyl and alkylether compounds

C - Chemistry, Metallurgy

07

D

C07D 239/46 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 239/56 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 471/04 (2006.01) C07D 491/044 (2006.01)

Patent

CA 2172809

The subject invention relates to pyrimidine-thioalkyl and alkylether compounds of Formula (I) and pyrimidine-thioalkyl and alkylethers of Formula (IA), namely the compounds of Formula (I) where R4 is selected from the group consisting of -H or -NR15R16 where R15 is -H and R16 is -H, C1-C6 alkyl, -NH2 or R15 and R16 taken together with the -N form 1-pyrrolidino, 1-morpholino or 1-piperidino; and R6 is selected from the group consisting of -H, or halo (preferably -Cl); with the overall proviso that R4 and R6 are not both -H. The compounds of Formula (IA) are useful in the treatment of individuals who are HIV positive.

L'invention concerne des composés à base de pyrimidine-thioalkyle et d'alkyléther de formule (I) ainsi qu'à base de pyrimidine-thioalkyle et d'alkyléther de formule (IA), c'est-à-dire ceux de la formule (I) où R¿4? est choisi dans le groupe consistant en -H ou -NR¿15?R¿16? où R¿15? représente -H et R¿16? représente -H, C¿1-6? alkyle, -NH¿2? ou bien où R¿15? et R¿16? pris conjointement avec le -N forment 1-pyrrolidino, 1-morpholino ou 1-piperidino; et R¿6? est choisi dans le groupe consistant en -H ou halo (de préférence -Cl); à la condition générale que R¿4? et R¿6? ne représentent pas tous les deux -H. Les composés de la formule (IA) se révèlent utiles pour traiter des personnes séropositives au VIH.

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