Pyrimidine urea derivatives as kinase inhibitors

Details Pyrimidine urea derivatives as kinase inhibitors Pyrimidine urea derivatives as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 239/48 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01) C07D 251/48 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2570873

The invention relates to compounds of formula (I) wherein the substituents X1, R1, R2, R3 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, and a method for the treatment of such a disease.

La présente invention a trait à des composés organiques de formule (I) dans laquelle les substituants X1, R1, R2, R3 et R4 sont tels que définis et détaillés dans la description, à des procédés pour la préparation de ces composés, à des compositions pharmaceutiques contenant lesdits composés, à leur utilisation en combinaison avec un ou des composés pharmaceutiquement actifs pour le traitement d'une maladie qui réagit à l'inhibition de l'activité de la protéine kinase, et à un procédé pour le traitement d'une telle maladie.

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