Pyrimidinecarboxamide derivatives as inhibitors of syk kinase

Details Pyrimidinecarboxamide derivatives as inhibitors of syk kinase Pyrimidinecarboxamide derivatives as inhibitors of syk kinase

C - Chemistry, Metallurgy

07

D

C07D 405/12 (2006.01) A61K 31/506 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2749403

The compound of formula (1) or a salt, preferably a pharmaceutically acceptable salt, thereof; is an inhibitor of spleen tyrosine kinase (SYK) and therefore potentially of use in treating diseases resulting from inappropriate mast cell activation, for instance allergic and inflammatory diseases, as well of potential use in cancer therapy, specifically heme malignancies.

La présente invention concerne le composé de formule (I) ou un sel, de préférence un sel pharmaceutiquement acceptable, de celui-ci; qui est un inhibiteur de la tyrosine kinase splénique (spleen tyrosine kinase : SYK) et qui peut être potentiellement utilisé pour traiter des maladies résultant d'une activation inappropriée des cellules mastocytes, par exemple des maladies allergiques et inflammatoires, mais également potentiellement utilisé dans une thérapie du cancer, en particulier des malignités héminiques.

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