C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 413/14 (2006.01)
Patent
CA 2746810
The present invention provides pyrimidinediamine compounds useful for inhibiting kinase activity, including the activity of polo-like kinase 1 (PLK1). Also provided are pharmaceutical compositions comprising these compounds and methods of treating diseases associated with kinase activity, in particular enhanced PLK1 catalytic activity, such as diseases associated with abnormal cell proliferation, including neoplastic disorders.
La présente invention porte sur des composés pyrimidinediamines utiles pour inhiber une activité kinase, comprenant l'activité de la kinase 1 de type polo (PLK1). L'invention porte également sur des compositions pharmaceutiques comprenant ces composés et sur des procédés de traitement de maladies associées à une activité kinase, en particulier une activité catalytique PLK1 accrue, telles que des maladies associées à une prolifération cellulaire anormale, comprenant des troubles néoplasiques.
Atuegbu Andy
Bhamidipati Somasekhar
Clough Jeffrey
Gelman Marina
Li Hui
Riches Mckenzie & Herbert Llp
Rigel Pharmaceuticals Inc.
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