Pyrimidines as inhibitors of phosphoinositide -3-kinases (pi3k)

Details Pyrimidines as inhibitors of phosphoinositide -3-kinases (pi3k) Pyrimidines as inhibitors of phosphoinositide -3-kinases (pi3k)

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/506 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2543608

The present invention provides pyrimidines of Formula (I): wherein R4, R6, and Y have any of the values defined therefor in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cardiovascular diseases, and cancers. Also provided are pharmaceutical compositions comprising one or more compounds of Formula (I).

La présente invention se rapporte à des pyrimidines répondant à la formule I, dans laquelle R?4¿, R?6¿ et Y ont l'une quelconque des notations définies dans la description, et leurs sels pharmaceutiquement acceptables, utilisables comme agent destiné au traitement des maladies et affections telles que les maladies inflammatoires, les maladies cardio-vasculaires et cancer. On l'a également prévu des compositions pharmaceutiques comportant un ou plusieurs composés répondant à la formule I.

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