Pyrimidines as kinase inhibitors

Details Pyrimidines as kinase inhibitors Pyrimidines as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/506 (2006.01) A61P 19/10 (2006.01)

Patent

CA 2711637

Compounds of formula (I) in free or salt or solvate form, where T1, T2, and T3 have the meanings as indicated in the specification, are useful for treating inflammatory or obstructive airways, pulmonary hypertension, pulmonary fibrosis, liver fibrosis, muscle diseases and systemic skeletal disorders. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

L'invention concerne des composés de la formule (I) sous forme libre, de sel ou de solvate, T1, T2 et T3 ayant les significations indiquées dans la description, qui sont utiles pour le traitement des troubles inflammatoires ou obstructifs des voies aériennes, de l'hypertension pulmonaire, de la fibrose pulmonaire, de la fibrose hépatique, des maladies musculaires et des troubles squelettiques systémiques. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés et des procédés pour la préparation des composés.

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