Pyrimidines as plk inhibitors

Details Pyrimidines as plk inhibitors Pyrimidines as plk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5513 (2006.01) A61K 31/553 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 239/48 (2006.01) C07D 401/12 (2006.01) C07D 403/14 (2006.01) C07D 405/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2573371

The invention relates to compounds of general formula (1), wherein A, W, X, Y, Z, Ra, Rb, Rc, R1, and R3 are defined as indicated in claim 1. Said compounds are used for the treatment of diseases characterized by excessive or anomalous cell proliferation. Also disclosed is the use of the inventive compounds for producing a medicament having said properties.

La présente invention concerne des composés de formule générale (1), dans laquelle A, W, X, Y, Z, Ra, Rb, Rc, R1 et R3 sont tels que définis dans la revendication n°1, ces composés étant adaptés au traitement de maladies caractérisées par une prolifération cellulaire excessive ou anormale. L'invention concerne également l'utilisation de ces composés pour produire un médicament présentant les propriétés susmentionnées.

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