C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/506 (2006.01) A61P 29/00 (2006.01) C07D 239/50 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2624450
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a human or animal subject such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis (Formula I).
L'invention concerne des composés qui lient VLA-4. Certains de ces composés inhibent aussi l'adhérence leucocytaire et notamment l'adhérence leucocytaire à médiation par VLA-4. Ces composés sont utiles dans le traitement de maladies inflammatoires chez un patient mammifère (p.ex., un humain) telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, la démence liée au SIDA, le diabète, la maladie intestinale inflammatoire, l'arthrite rhumatoïde, la transplantation de tissu, la métastase tumorale et l'ischémie myocardique. Les composés peuvent aussi être administrés lors du traitement de maladies inflammatoires du cerveau telles que la sclérose en plaques (Formule I).
Fukuda Juri Y.
Konradi Andrei W.
Rossiter Kassandra Inez
Semko Christopher Michael
Smith Jenifer Lea
Elan Pharmaceuticals Inc.
Ridout & Maybee Llp
Wyeth
LandOfFree
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