Pyrimidinyl-glutamic acid derivatives

Details Pyrimidinyl-glutamic acid derivatives Pyrimidinyl-glutamic acid derivatives

C - Chemistry, Metallurgy

07

D

C07D 239/28 (2006.01) A61K 31/505 (2006.01) A61K 31/675 (2006.01) A61K 31/695 (2006.01) C07D 239/42 (2006.01) C07D 239/48 (2006.01) C07D 401/06 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 409/12 (2006.01) C07F 7/10 (2006.01) C07F 9/6512 (2006.01)

Patent

CA 2173234

The present invention provides novel pyrimidinyl-glutamic acid derivatives and intermediates thereto. Further provided are methods for inhibiting dihyfrofolate reductase in mammals and for treating susceptible neoplasms in mammals, particularly humans.

L'invention se rapporte à des nouveaux dérivés de l'acide pyrimidinylglutamique ainsi qu'aux intermédiaires de ces dérivés. L'invention concerne en outre des procédés servant à inhiber la dihydrofolate réductase chez les mammifères et destinés au traitement des tumeurs sensibles chez ceux-ci et notamment chez l'homme.

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