C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/48 (2006.01) A61K 31/506 (2006.01) A61P 25/00 (2006.01)
Patent
CA 2682817
The present invention relates to new dopamine D3 and D2 ligands of formula (I): wherein Rl, R2 and Q are as described herein, and/or geometric isomers and/or stereoisomers and/or diastereomers and/or salts and/or hydrates and/or solvates and/or polymorphs thereof. The invention also relates to processes for preparing the same, to compositions containing the same and to their use in the treatment and/or prevention of conditions which requires modulation of dopamine receptors.
La présente invention concerne de nouveaux ligands des récepteurs D3 et D2 de la dopamine répondant à la formule (I), dans laquelle Rl, R2 et Q sont tels que décrits ici, et/ou des isomères géométriques et/ou des stéréoisomères et/ou des diastéréomères et/ou des sels et/ou des hydrates et/ou des solvates et/ou des polymorphes desdits ligands. L'invention concerne également des procédés de préparation desdits ligands, des compositions les contenant et leur utilisation pour traiter et/ou prévenir les troubles nécessitant une modulation des récepteurs de la dopamine.
Againe Csongor Eva
Bartane Szalai Gizella
Domany Gyorgy
Farkas Sandor
Gyertyan Istvan
Fetherstonhaugh & Co.
Richter Gedeon Nyrt.
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