Pyrimidinyl pyridone inhibitors of jnk.

Details Pyrimidinyl pyridone inhibitors of jnk. Pyrimidinyl pyridone inhibitors of jnk.

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01)

Patent

CA 2719868

This application discloses novel pyrimidinyl pyridone derivatives according to formula (I), wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula (I) and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.

L'invention concerne de nouveaux dérivés de pyrimidinyle pyridone de la formule (I), dans laquelle A, R1, R2, R3, et m sont tels que définis dans la description, qui inhibent JNK. Les composés selon l'invention sont utiles pour moduler l'activité de JNK et traiter les maladies associées à une activité JNK excessive. Lesdits composés permettent de traiter les maladies autoimmunes, inflammatoires, métaboliques et neurologique et le cancer. L'invention se rapporte aussi à des compositions renfermant le composé de la formule (I) et à des procédés de traitement qui consistent à administrer une quantité thérapeutiquement efficace du composé de la formule I à un sujet qui en a besoin.

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