C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2734037
This application discloses novel pyrimidinyl pyridone derivatives according to Formulae I and II, wherein R1 and are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of Formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of Formula I to a subject in need thereof.
La présente invention concerne de nouveaux dérivés de pyrimidinylpyridone selon les formules I et II, où R1 et R2 sont définis comme présentement décrit, qui inhibent JNK. Les composés présentement décrits sont utiles pour moduler lactivité de JNK et traiter des maladies associées à une activité JNK excessive. Les composés sont utiles pour traiter des maladies auto-immunes, inflammatoires, métaboliques et neurologiques ainsi que le cancer. La présente invention concerne en outre des compositions comprenant le composé de formule I et des procédés de traitement comprenant ladministration dune quantité thérapeutiquement efficace du composé de formule I à un sujet nécessitant celle-ci.
Boice Genevieve N.
Gong Leyi
Mccaleb Kristen Lynn
Palmer Wylie Solang
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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