Pyrimido(4,5-g)quinolines and intermediates

Details Pyrimido(4,5-g)quinolines and intermediates Pyrimido(4,5-g)quinolines and intermediates

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 471/04 (2006.01)

Patent

CA 1234112

ABSTRACT OF THE DISCLOSURE Trans-(+)-2-Amino (or substituted amino)-4- (permissibly-substituted)-6-C1-C3 alkyl (or allyl)-5,5a,- 6,7,8,9,9a,10-octahydropyrimido[4,5-g]quinolines, the corresponding trans-(-) and trans-(+)-stereoisomers and salts thereof, useful in treating Parkinson's Syndrome, sexual dysfunction, depression, hypertension, and prolactin related diseases, and intermediates useful for the synthesis thereof, are disclosed. The products are prepared by condensing an appropriate ketone with the appropriately substltuted guanidine.

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