Pyrimido[5,4-d]pyrimidines, medicaments comprising these...

Details Pyrimido[5,4-d]pyrimidines, medicaments comprising these... Pyrimido[5,4-d]pyrimidines, medicaments comprising these...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 519/00 (2006.01) C07F 9/547 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2199401

The present invention relates to pyrimido[5,4-d]pyrimidines of the general formula (see formula I) in which R a to R c are as defined in Claim 1, their tautomers, their stereoisomers and their salts, in particular their physiologically tolerated salts with inorganic or organic acids or bases which have valuable pharmacological properties, in particular an inhibiting action on signal transduction mediated by tyrosine kinases, their use for the treatment of diseases, in particular tumour diseases, and their preparation.

La présente invention concerne des pyrimido[5,4-d]pyrimidines de formule générale (I) où Ra à Rc sont définis dans la revendication 1, leurs tautomères, leurs stéréo-isomères et leurs sels, notamment leurs sels physiologiquement acceptables contenant des acides ou des bases inorganiques ou organiques. Ces composés présentent des propriétés pharmacologiques, notamment un effet inhibiteur sur la transduction de signaux effectuée par l'intermédiaire des tyrosines kinases. L'invention concerne également leur utilisation pour le traitement de maladies, notamment de maladies tumorales, ainsi que leur procédé de fabrication.

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