C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01) C07D 239/42 (2006.01) C07D 239/46 (2006.01)
Patent
CA 2521124
Disclosed are novel pyrimido compounds of the formula (I) that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and the use for treating cancer.
L'invention porte sur de nouveaux composés pyrimido de formule (I) inhibiteurs sélectifs des kinases KDR et FGFR. Lesdits composés et leurs sels pharmacocompatibles sont des agents antiprolifératifs utilisables pour le traitement de tumeurs solides en particulier du sein, du colon des poumons et de la prostate. L'invention porte également sur des préparations pharmaceutiques les contenant et sur leur utilisation pour le traitement du cancer.
Chen Yi
Dermatakis Apostolos
Liu Jin-Jun
Luk Kin-Chun
Michoud Christophe
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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