C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 239/00 (2006.01)
Patent
CA 2494127
Disclosed are novel pyrimido compounds of the formula I that are selective inhibitors of both KDR and FGFR kinases and are selective against LCK. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon, lung and prostate tumors. Also disclosed are pharmaceutical compositions containing these compounds and a process for their preparation.
La présente invention concerne de nouveaux composés pyrimido de formule I qui sont des inhibiteurs sélectifs des kinases KDR et FGFR et sont sélectifs contre les LCK. Lesdits composés et leurs sels pharmaceutiquement acceptables sont des agents antiprolifératifs utiles dans le traitement ou le contrôle de tumeurs solides, en particulier de tumeurs du sein, du côlon, du poumon et de la prostate. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés ainsi qu'un procédé de préparation de ces derniers.
Chen Yi
Daniewski Andrzej Robert
Harris William
Kabat Marek Michal
Liu Emily Aijun
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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