Pyrimido-diazepinone kinase scaffold compounds and methods...

Details Pyrimido-diazepinone kinase scaffold compounds and methods... Pyrimido-diazepinone kinase scaffold compounds and methods...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/4985 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 487/12 (2006.01)

Patent

CA 2748181

The present invention relates to novel pyrimido-diazepinone compounds, methods of modulating protein kinases, including MPS1 (TTK), ERK5 (BMK1, MAPK7), polo kinase 1,2,3, or 4, Ack1, Ack2, AbI, DCAMKL1, ABL1, AbI mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNK1, PLK1, ULK2, PLK4, PRKD1, PRKD2, PRKD3, ROS 1, RPS6KA6, TAOK1, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, AxI, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB and TrkC, and the use of such compounds in the treatment of various diseases, disorders or conditions.

La présente invention porte sur de nouveaux composés pyrimido-diazépinone, sur des procédés de modulation de protéines kinases comprenant MPSl (TTK), ERK5 (BMKl, MAPK7), polo kinase 1,2,3 ou 4, Ackl, Ack2, AbI, DCAMKLl, ABLl, AbI mutants, DCAMKL2, ARK5, BRK, MKNK2, FGFR4, TNKl, PLKl, ULK2, PLK4, PRKDl, PRKD2, PRKD3, ROS l, RPS6KA6, TAOKl, TAOK3, TNK2, Bcr-Abl, GAK, cSrc, TPR-Met, Tie2, MET, FGFR3, Aurora, AxI, Bmx, BTK, c-kit, CHK2, Flt3, MST2, p70S6K, PDGFR, PKB, PKC, Raf, ROCK-H, Rskl, SGK, TrkA, TrkB et TrkC, et sur l'utilisation de tels composés dans le traitement de diverses maladies, de divers troubles ou de diverses affections.

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