Pyrimido-pyrimidine lipoxygenase inhibiting compounds

Details Pyrimido-pyrimidine lipoxygenase inhibiting compounds Pyrimido-pyrimidine lipoxygenase inhibiting compounds

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01)

Patent

CA 2050295

2050295 9009996 PCTABS00002 Compounds of the formula (I), wherein A is selected from NR1R2 and N(OR6)R2; and B and C are chloro when A is N(OR6)R2 or are independently selected from NHR3 and NR4R5 where R1, R2, R3, R4 and R5 are independently selected from the group consisting of alkyl, cycloalkyl and alkylaryl each of which may be unsubstituted or substituted with one or more substituents selected from the group consisting of hydroxy, OR, NRR, OCOR, OCONRR, NRCOR and NRCONRR where R is selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, alkoxy and hydroxy or R1 and R2 or R4 and R5 together can form a heteroaryl group and R6 is a member selected from the group consisting of hydrogen, alkyl, alkylaryl and trialkylsilyl; and the pharmaceutically acceptable salts thereof. These compounds are useful as inhibitors of lipoxygenase enzymes.

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