Pyrimidone derivatives

Details Pyrimidone derivatives Pyrimidone derivatives

C - Chemistry, Metallurgy

07

D

167/208, 260/242

C07D 471/04 (2006.01) C07D 239/62 (2006.01) C07D 487/04 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01)

Patent

CA 1237429

RAN 4044/62 Abstract Pyrimidone derivatives of the formula Image I wherein n is the number 1 or 0, X, A1 and A2 are optionally mono-lower alkylated or di-lower alkylated methylene, or X is optionally lower alkylated nitrogen, R is hydrogen or lower-alkyl and Y and Z together are a group =NR5, or R and Z together are a N-C-bond and Y is a group -N(H)R5, R1, R2 and R3 are hydrogen, lower-alkyl or lower-alkoxy, or two of R1, R2 and R3 on adjacent carbon atoms are methylenedioxy or ethylenedioxy, R4 is hydrogen or lower-alkyl, R5 is phenyl optionally substituted by R6, R7 and R8, and R6, R7 and R8 are chlorine, fluorine, bromine, lower-alkyl or lower-alkoxy, with the proviso that at least one of the methylene groups A1 and A2 is mono-lower alkylated ox di-lower alkylated when R4 is hydrogen and n is the number 0, and physiologically compatible salts thereof have blood platelet aggregation-inhibiting activity or have activity on the circulatory system. These compounds are obtained starting from corres- ponding chlorinated or brominated pyrimidone derivatives.

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