Pyrimidone derivatives

Details Pyrimidone derivatives Pyrimidone derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/506 (2006.01) C07D 401/14 (2006.01) C07D 409/14 (2006.01)

Patent

CA 2345065

A pyrimidone derivative represented by formula (I) or a salts thereof: wherein R1 represents an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group and the like; R2 represents a hydrogen atom, hydroxyl group, an alkyl group, an alkenyl group and the like, R3 represents a pyridyl group, and a medicament comprising said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a disease caused by tau protein kinase l hyperactivity such as Alzheimer disease.

L'invention concerne un dérivé pyrimidone, correspondant à la formule (I), ou un sel de celui-ci. Dans cette formule R?1¿ représente un groupe alkyle, un groupe alcényle, un groupe alcynyle, un groupe cycloalkyle, un groupe aryle, et analogue; R?2¿ représente un atome d'hydrogène, un groupe hydroxyle, un groupe alkyle, un groupe alcényle et analogue, et R?3¿ représente un groupe pyridyle. L'invention concerne également un médicament, lequel comprend ce dérivé ou un sel de celui-ci, en tant que principe actif, et est utile dans le traitement préventif et/ou thérapeutique d'une maladie provoquée par l'hyperactivité de la protéine tau kinase I, telle que la maladie d'Alzheimer.

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