Pyrimidone derivatives and analogs in the treatment of...

A - Human Necessities – 61 – K

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A61K 31/505 (2006.01) A61K 31/415 (2006.01)

Patent

CA 2029704

PYRIMIDONE DERIVATIVES AND ANALOGS IN THE PC7641A TREATMENT OF ASTHMA OR CERTAIN SKIN DISORDERS Abstract Racemic or optically active compound of the formula Image wherein X is O or NH, R1 is a (C7-C11)polycycloalkyl group, R2 is methyl or ethyl, Y is Image or Image ; R3 is hydrogen, (C1-C3)alkyl, (C2-C3)alkenyl, benzyl or phenethyl, and R4 is hydrogen, (C1-C3)alkyl or (C2-C3)alkanoyl, are useful in the treatment of asthma or inflammatory airway or skin diseases.

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