Pyrimidyl cyclopentanes as akt protein kinase inhibitors

Details Pyrimidyl cyclopentanes as akt protein kinase inhibitors Pyrimidyl cyclopentanes as akt protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/12 (2006.01) A61K 31/517 (2006.01) A61K 31/5377 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2692502

The present invention provides compounds of Formula (I), including tau-tomers, resolved enantiomers, diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.

L'invention concerne des composés représentés par la formule (I), y compris des tautomères, des énantiomères résolus, des diastéréomères, des solvates, des métabolites, des sels et des promédicaments pharmaceutiquement acceptables de ceux-ci. L'invention concerne aussi des procédés d'utilisation des composés de l'invention comme inhibiteurs de protéines kinases AKT et dans le traitement de maladies hyperprolifératives telles que le cancer.

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