Pyrimidylaminobenzamide derivatives for hypereosinophilic...

A - Human Necessities – 61 – K

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A61K 31/506 (2006.01) A61P 7/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2606068

The present invention relates to the use of pyrimidylaminobenzamide derivatives for the preparation of a drug for the treatment of FIP1L1- PDGFR.alpha.-induced or TEL-PDGFR.beta.-induced myeloproliferative diseases, especially for the curative and/or prophylactic treatment of hypereosinophilic syndrome and hypereosinophilc syndrome with resistance to imatinib, and to a method of treating hypereosinophilic syndrome, chronic eosinophilic leukemia and hypereosinophilic syndrome with resistance to imatinib, or other diseases associated with FIP1L1-PDGFR.alpha., TEL-PDGFR.beta. or similar mutations that activate PDGFR.

La présente invention concerne l'utilisation de dérivés de pyrimidylaminobenzamide pour la préparation d'un médicament destiné au traitement de maladies myéloprolifératives induites par FIP1L1-PDGFRa ou induites par TEL-PDGFRß, notamment destiné au traitement curatif et/ou prophylactique du syndrome hyperéosinophilique et du syndrome hyperéosinophilique à résistance à l'imatinib, ainsi qu'une méthode de traitement du syndrome hyperéosinophilique, de la leucémie éosinophilique chronique et du syndrome hyperéosinophilique à résistance à l'imatinib, ou d'autres maladies associées à FIP1L1-PDGFRa, TEL-PDGFRß ou des mutations similaires qui activent le PDGFR.

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