Pyrimidylpyrrole derivatives active as kinase inhibitors

Details Pyrimidylpyrrole derivatives active as kinase inhibitors Pyrimidylpyrrole derivatives active as kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 45/06 (2006.01) A61P 9/10 (2006.01) A61P 11/00 (2006.01) A61P 13/08 (2006.01) A61P 13/12 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 25/28 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01) C07D 519/00 (2006.01)

Patent

CA 2534496

Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

L'invention concerne des dérivés de pyrimidylpyrrole représentés par la formule générale (1) ainsi que des sels de qualité pharmaceutiques de ces dérivés, tels qu'ils sont décrits dans la description, des procédés destinés à la préparation de ces dérivés et des compositions pharmaceutiques comprenant ces dérivés. Les composés de l'invention peuvent être utilisés pour le traitement de maladies associées à un dérèglement de l'activité de la protéine kinase, telles que le cancer.

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