C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/078 (2006.01) A61K 38/05 (2006.01) A61P 29/00 (2006.01) C07K 5/06 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2358093
Disclosed are pyroglutamic acid derivatives and related compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.
La présente invention concerne des dérivés d'acide pyroglutamique et des composés associés à liaison VLA-4. Certains de ces composés sont également inhibiteurs de l'adhésion leukocytaire, notamment de l'adhésion leukocytaire à médiation de VLA-4. De tels composés conviennent, chez un mammifère tel qu'un humain, au traitement d'affections inflammatoires telles que l'asthme, la maladie d'Alzheimer, l'athérosclérose, le syndrome démentiel du SIDA, le diabètes, certaines colopathies, la polyarthrite rhumatoïde, les greffes de tissus, les métastases tumorales et l'ischémie myocardique. Ces composés conviennent également au traitement d'affections cérébrales inflammatoires telles que la sclérose en plaques.
Dressen Darren B.
Kreft Anthony
Kubrak Dennis
Mann Charles William
Pleiss Michael A.
American Home Products Corporation
Elan Pharmaceuticals Inc.
Torys Llp
Wyeth
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