C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 309/38 (2006.01) A61K 31/365 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) C07D 335/02 (2006.01) C07D 403/06 (2006.01) C07D 405/04 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 407/04 (2006.01) C07D 407/12 (2006.01) C07D 413/12 (2006.01) C07F 7/18 (2006.01)
Patent
CA 2176044
The present invention relates to novel tri- and tetrasubstituted pyrones and related structures which potently inhibit the HIV aspartyl protease blocking HIV infectivity. The pyrone derivatives are useful in the development of therapies for the treatment of bacterial and viral unfections and diseases, including AIDS. The present invention is also directed to methods of synthesis of multifunctionalized pyrones and of related structures.
La présente invention se rapporte à des nouvelles pyrones trisubstituées et tétrasubstituées ainsi qu'à leurs structures associées, qui inhibent puissamment l'aspartyle protéase du VIH en bloquant le pouvoir infectant du VIH. Ces dérivés de la pyrone sont utiles dans le développement des thérapies destinées au traitement des infections et maladies bactériennes et virales, notamment le SIDA. La présente invention se rapporte également à des procédés de synthèse de pyrones multifonctionnalisées et de structures apparentées.
Domagala John Michael
Lunney Elizabeth
Para Kimberly Suzanne
Prasad Josyula Venkata Nagendra Vara
Tait Bradley Dean
Macrae & Co.
Warner-Lambert Company
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