Pyropheophorbides and their use in photodynamic therapy

Details Pyropheophorbides and their use in photodynamic therapy Pyropheophorbides and their use in photodynamic therapy

C - Chemistry, Metallurgy

07

D

C07D 487/22 (2006.01) A61K 31/40 (2006.01) A61K 41/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2125189

Pyropheophorbide compounds are injected into a host and accumulate in tumor tissue to a higher degree than surrounding normal tissues. When the pyropheophorbide compounds are exposed to a particular wavelength of light the compounds become cytotoxic and destroy the tumor or diseased tissue without causing irreversible normal tissue damage. The pyropheophorbide compounds have shown improved results as compared to drugs currently used in photodynamic therapy. Further, they absorb light further in the red, optimizing tissue penetration and are retained in the skin for short time periods relative to other drugs used in photodynamic therapy.

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