C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/34 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61P 25/18 (2006.01) A61P 25/24 (2006.01) C07D 207/36 (2006.01) C07D 231/14 (2006.01) C07D 401/10 (2006.01) C07D 403/04 (2006.01) C07D 403/10 (2006.01) C07D 405/10 (2006.01) C07D 409/10 (2006.01) C07D 409/12 (2006.01) C07D 413/10 (2006.01) C07D 417/10 (2006.01)
Patent
CA 2541458
The present invention relates to pyrrole and pyrazole compounds of formula (I) and their pharmaceutically acceptable salts, and further relates to their use in treating schizophrenia, cognitive deficits associated with schizophrenia, Alzheimer's disease, dementia of the Alzheimer's type, mild cognitive impairment, or depression. The compounds act as potentiators on glutamate receptors, in particular AMPA and the GluR family.
L'invention concerne des composés de pyrrole et pyrazole, leurs sels pharmaceutiquement acceptables, ainsi que leur utilisation pour traiter la schizophrénie, les déficits cognitifs associés à la schizophrénie, la maladie d'Alzheimer, la démence de type Alzheimer, la déficience cognitive légère, ou la dépression. Ces composés ont un effet potentiateur sur les récepteurs du glutamate, en particulier AMPA et la famille GluR.
Albaugh Pamela Ann
Castano Mansanet Ana Maria
Dominguez-Manzanares Esteban
Hong Jian Eric
Hornback William Joseph
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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