Pyrrole based inhibitors of glycogen synthase kinase 3

Details Pyrrole based inhibitors of glycogen synthase kinase 3 Pyrrole based inhibitors of glycogen synthase kinase 3

C - Chemistry, Metallurgy

07

D

C07D 401/12 (2006.01) A61K 31/4439 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 453/02 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2496246

New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitroand of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.

L'invention concerne de nouveaux composés à base de pyrrole, des compositions et des procédés permettant d'inhiber l'activité de la glycogène synthase kinase (GSK3) <i>in vitro </i> et de traiter des troubles induits par la GSK3 <i>in vivo </i>. Les procédés, composés et compositions de l'invention peuvent être employés seuls, ou en combinaison avec d'autres agents pharmacologiquement actifs dans le traitement de troubles induits par l'activité de la GSK3, tels que le diabète, la maladie d'Alzheimer et d'autres maladies neurodégénératives, l'obésité, les maladies cardio-vasculaires athéroscléreuses, l'hypertension artérielle essentielle, le syndrome des ovaires polykystiques, le syndrome X, l'ischémie, les lésions cérébrales traumatiques, les troubles bipolaires, l'immunodéficience ou le cancer.

Affiliated with

Also associated with

Rating

Pyrrole based inhibitors of glycogen synthase kinase 3 does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrole based inhibitors of glycogen synthase kinase 3, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrole based inhibitors of glycogen synthase kinase 3 will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1709980