Pyrrole derivatives

Details Pyrrole derivatives Pyrrole derivatives

C - Chemistry, Metallurgy

07

D

C07D 207/48 (2006.01) A61K 31/40 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/06 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2046146

Compounds of the present invention are represented by the formula (I). Image ( I ) wherein R1, R2, and R3 each is independently hydrogen, optionally substituted lower alkyl, or optionally substituted aryl; R4 is lower alkyl, aralkyl, aryl, or heteroaryl, each of which is optionally substituted; X is vinylene or ethylene; Y is Image or Image where R5 is hydrogen, lower alkyl, aryl, aralkyl, or a cation capable of forming a non-toxic pharmaceutically acceptable salt. The compounds of the present invention inhibit the HMG-CoA reductase, and subsequently suppress the synthesis of cholesterol. They are useful in the treatment of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.

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