Pyrrole derivatives as antimycobacterial compounds

Details Pyrrole derivatives as antimycobacterial compounds Pyrrole derivatives as antimycobacterial compounds

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/496 (2006.01) A61K 31/497 (2006.01) A61K 31/5377 (2006.01) A61K 31/541 (2006.01) A61P 31/06 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01)

Patent

CA 2499701

Novel pyrrole derivatives of formula (I), and their pharmaceutically acceptable acid addition salts having superior antimycobacterial activity against clinically sensitive as well as resistant strains of Mycobacterium tuberculosis as well as having lesser toxicity compared to known compounds. The use of the novel compounds of formula (I) for treatment of latent tuberculosis including Multi Drug Resistant Tuberculosis (MDR TB). The methods for preparation of the novel compounds, pharmaceutical compositions containing the novel compounds and method of treating MDR TB by administration of compounds of formula (I).

L'invention concerne de nouveaux dérivés de pyrrole de formule (I) et leurs sels d'addition acides pharmaceutiquement acceptables ayant une activité anti-mycobactérienne supérieure par rapport à une sensibilité clinique ainsi que des souches résistantes de bacille de Koch ainsi qu'une toxicité moindre par rapport aux composés connus. L'utilisation des nouveaux composés de formule (I) dans le traitement de la tuberculose latente, y compris la tuberculose multirésistante aux antibiotiques (MDR TB). Les procédés de préparation des nouveaux composés, des compositions pharmaceutiques contenant les nouveaux composés et une méthode de traitement de la MDR TB par l'administration de composés de formule (I) font également l'objet de cette invention.

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