Pyrrole derivatives as phosphodiesterase vii inhibitors

Details Pyrrole derivatives as phosphodiesterase vii inhibitors Pyrrole derivatives as phosphodiesterase vii inhibitors

A - Human Necessities

61

K

A61K 31/402 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2389709

Compounds of the formula I (see formula I) in which R1 and R2, independently of one another, each denote H, A, OA, SA or Hal, R3 denotes H or A, R4 denotes A or NH2, R5 denotes H, NH2, NHA or NA2, A denotes alkyl having 1 to 10 carbon atoms, alkenyl, cycloalkyl or alkylenecycloalkyl, Hal denotes F, Cl, Br or I, and their physiologically acceptable salts and/or solvates, as phosphodiesterase VII inhibitors.

L'invention concerne des composés de formule (I), dans laquelle R<1>, R<2> représentent indépendamment l'un de l'autre H, A, OA, SA ou Hal ; R<3> représente H ou A ; R<4> représente A ou NH2 ; R<5> représente H, NH2, NHA ou NA2 ; A représente alkyle comportant 1 à 10 atomes de C, alcényle, cycloalkyle ou alkylènecycloalkyle ; Hal représente F, Cl, Br ou I. L'invention concerne également les sels et/ou solvates physiologiquement tolérables de ces composés, qui servent, comme ces derniers, d'inhibiteurs de la phosphodiestérase VII.

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