Pyrrole derivatives, their preparation and their therapeutic...

Details Pyrrole derivatives, their preparation and their therapeutic... Pyrrole derivatives, their preparation and their therapeutic...

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/435 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2576717

The invention concerns compounds of formula (I), wherein: R1 represents hydrogen or a C1-C4 alkyl; R2 represents a C4-C10 group, a non-aromatic carbocyclic C3-C12 radical, an indianyl, a 1,2,3,4-tetrahydronaphthalenyl -1 or 2, a heterocyclic radical, a substituted C1-C3 alkylene group, a NR10R11 group; or R1 and R2 together with the nitrogen atom whereto they are bound form a heterocyclic radical. The invention also concerns the method for preparing said compounds and their therapeutic use.

L~invention a pour objet et des composés répondant à la formule (I) : dans laquelle : R1 représente l'hydrogène ou un (C1-C4)alkyle ; R2 représente : un groupe (C4-C10) ; un radical carbocyclique non aromatique en C3-C12 ; un indanyle ; un 1,2,3,4-tétrahydronaphtalényle -1 ou -2 ; un radical hétérocyclique ; un groupe (C1-C3) alkylène substitué ; un groupement NR10R11 ; ou R1et R2 ensemble avec l~atome d~azote auquel ils sont liés constituent radical hétérocyclique. Procédé de préparation et application en thérapeutique.

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