Pyrrole substituted 2-indolinone protein kinase inhibitors

Details Pyrrole substituted 2-indolinone protein kinase inhibitors Pyrrole substituted 2-indolinone protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/06 (2006.01) A61K 31/404 (2006.01) A61P 43/00 (2006.01) C07D 207/33 (2006.01) C07D 209/44 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2399358

The present invention relates to pyrrole substituted 2-indolinone compounds of formula (1): and their pharmaceutically acceptable salts which modulate the activity of protein kinases and therefor are expected to be useful in the prevention and treatment of protein kinase related cellular disorders such as cancer.

La présente invention concerne des composés de 2-indolinone à substitution pyrrole, ainsi que leurs sels pharmaceutiquement acceptables, modulant l'activité de la protéine kinase et donc utiles dans la prévention et le traitement des dysfonctionnements cellulaires liés à la protéine kinase, tels que le cancer.

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