C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/233, 260/316
C07D 207/33 (2006.01) A61K 31/40 (2006.01) C07D 207/333 (2006.01) C07D 207/34 (2006.01)
Patent
CA 2032421
ABSTRACT OF THE DISCLOSURE: A novel pyrrolealdehyde derivative represented by the following formula (I): Image (I) wherein R represents C10-C16 alkyl unsubstituted or substituted by at least one substituent selected from the group consisting of halo, hydroxy, amino, carbamoyl, C1-C5 alkylamino, C2-C6 dialkylamino, C2-C6 acylamino, C1-C5 alkylthio, mercapto, C2-C6 acyloxy, carbamoyloxy, C6-C12 aryl and C3-C7 cycloalkyl; or C10-C16 alkenyl having at least one vinyl, and a pharmaceutically acceptable salt thereof are provided. The compounds are highly effective in reducing the level of triglyceride and cholesterol in serum, and useful as an active ingredient of a pharmaceutical composition for treating hyperlipemia and arteriosclerosis.
Hirata Mayumi
Shirasaka Tadashi
Taniguchi Masao
Umezu Kohei
Hirata Mayumi
Mitsubishi Chemical Corporation
Ridout & Maybee Llp
Shirasaka Tadashi
Taniguchi Masao
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