C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 5/02 (2006.01) A61K 38/04 (2006.01) C07C 323/60 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2370259
Compounds of formula (I) are described which have activity as anti- inflammatory agents. Cyclic disulfide compounds are provided which inhibit of binding of cells to endothelium. Such compounds are useful for treating inflammatory diseases, such as asthma, whose symptoms and/or damage are related to the binding of cell adhesion molecules to integrin expressing cells.
L'invention concerne des composés de formule (I) présentant l'activité d'agents anti-inflammatoires. L'invention concerne des composés disulfures cycliques inhibant la liaison des cellules à l'endothélium. Ces composés sont utilisés pour traiter des maladies inflammatoires, telles que l'asthme, dont les symptômes et/ou les lésions sont associés à la liaison des molécules d'adhésion cellulaire aux cellules exprimant l'intégrine.
Chen Li
Fotouhi Nader
Jackson David Young
Tilley Jefferson Wright
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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