C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/16 (2006.01) A61K 31/401 (2006.01) A61P 9/00 (2006.01) C07D 403/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2415665
The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the description and the claims and pharmaceutically acceptable esters and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.
La présente invention concerne des composés de la formule (1) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et X sont tels que définis dans la description et les revendications, et des esters et/ou des sels pharmaceutiquement acceptables de ces derniers. Les composés de l'invention sont utilisés comme inhibiteurs des métalloprotéases, par exemple les protéases du zinc, en particulier les hydrolases du zinc, et ils sont efficaces dans le traitement d'états maladifs associés à une vasoconstriction qui va en augmentant.
Aebi Johannes
Dehmlow Henrietta
Kitas Eric Argirios
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
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