Pyrrolidine and piperidine derivatives

Details Pyrrolidine and piperidine derivatives Pyrrolidine and piperidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 498/04 (2006.01) A61K 31/40 (2006.01) A61K 31/4025 (2006.01) A61K 31/42 (2006.01) A61K 31/424 (2006.01) A61K 31/437 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) A61K 31/5383 (2006.01)

Patent

CA 2260698

The present invention relates to the use of pyrrolidine and piperidine derivatives of the general formulae (see fig. I) and (see fig. II) and wherein R1 and R2 are, independently from each other, hydrogen, lower alkoxy, hydroxy, halogen, -CONH2 or -C(O)O-lower alkyl; or taken together are -O-CH2-O-; R3 and R4 are, independently from each other, hydrogen, lower alkoxy, benzyloxy, halogen, hydroxy, -CONH2 or -SCH3; or taken together are -O-CH2-O-; R5 is hydrogen or lower alkyl; X and Y are, independently from each other -CH(OH)-, -(CH2)n-, -C(O)- or -CH(lower alkoxy)-; and m, n and p are 1 or 2; and to their pharmaceutically acceptable addition salts for the treatment of diseases caused by overactivation of NMDA receptor subtypes.

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