A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01) A61K 31/435 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 211/68 (2006.01) C07D 217/02 (2006.01) C07D 223/16 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 495/10 (2006.01)
Patent
CA 2298813
The present invention is directed to pyrrolidine and piperidine compounds of formula (I), (wherein R1, R2, R3, R4a, R4b, R4c, R4d, R4e, R4f, R4g, R4h, m, n, x and y are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3, and/or CXCR-4.
L'invention concerne des composés de pyrrolidine et de pipéridine représentés par la formule (I) (dans laquelle R?1¿, R?2¿, R?3¿, R?4a¿, R?4b¿, R?4c¿, R?4d¿, R?4e¿, R?4f¿, R?4g¿, R?4h¿, m, n, x et y sont tels qu'ils sont définis dans le descriptif) et présentant une utilité en tant que modulateurs de l'activité du récepteur de chemokine. En particulier, ces composés sont utiles en tant que modulateurs des récepteurs de chemokine CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR-4, CCR-5, soit CXCR-3, soit CXCR-4.
Berk Scott C.
Budhu Richard J.
Hale Jeffrey J.
Holson Edward
Lynch Christopher
Merck & Co. Inc.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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