Pyrrolidine and piperidine prostaglandin analogues

Details Pyrrolidine and piperidine prostaglandin analogues Pyrrolidine and piperidine prostaglandin analogues

C - Chemistry, Metallurgy

07

D

260/324, 260/292

C07D 207/26 (2006.01) C07C 405/00 (2006.01) C07D 207/273 (2006.01) C07D 207/36 (2006.01) C07D 207/38 (2006.01) C07D 211/76 (2006.01)

Patent

CA 1085856

ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) wherein: m is 1 or 2; n is 4 to 8; X is CO, protected CO, or CROH wherein R is hydrogen or C1-4 alkyl and wherein the OH moiety may be protected; R1 is hydrogen or CO2R1 represents an ester group in which the R1 moiety contains from 1 to 12 carbon atoms; R3 is hydroxy, or protected hydroxy; R2 and R4 are separately hydrogen, C1-9 alkyl, C5-8 cycloalkyl, C5-8 cycloalkyl-C1-6 alkyl, phenyl, phenyl C1-6 alkyl, naphthyl, naphthyl C1-6 alkyl, any of which phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C1-6 alkyl, C1-6 alkoxy or nitro groups; or R2 and R4 taken with the carbon atom to which they are joined represent a C5-8 cycloalkyl group; and salts thereof; except that when one of R2 and R4 is hydrogen or C1-4 alkyl then the other of R2 and R4 cannot be hydrogen or C1-9 alkyl; have useful pharmacological properties including anti- gastric secretion, bronchodilator and platelet aggregration inhi- bition activities.

263940

Affiliated with

Also associated with

Rating

Pyrrolidine and piperidine prostaglandin analogues does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pyrrolidine and piperidine prostaglandin analogues, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pyrrolidine and piperidine prostaglandin analogues will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-266201