Pyrrolidine bicyclic compounds

Details Pyrrolidine bicyclic compounds Pyrrolidine bicyclic compounds

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61P 31/04 (2006.01) C07D 207/08 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 417/04 (2006.01)

Patent

CA 2446931

N-[1-oxo-(optionally 2-aza)-2-alkyl-3-(carboxyl or thiol or hydroxyaminocarbonyl or N-hydroxyformamido)-propyl]-(aryl or heteroaryl)- azacyclo4-7 alkanes or thiazacyclo4-7 alkanes, salts or prodrugs therof have interesting properties, e.g. in the treatment or prevention of disorders amenable to treatment by peptidyl deformylase inhibitors such as treatment of bacterial infections.

L'invention concerne des alkanes <I>N</I>-[1-oxo-(facultativement 2-aza)-2-alkyl-3-(carboxyl ou thiol ou hydroxyaminocarbonyle ou <I>N</I>-hydroxyformamido)-propyle]-(aryle ou hétéroaryle)-azacyclo¿4-7? ou des alkanes thiazacyclo¿4-7?, des sels ou des promédicaments de ces composés présentant des propriétés intéressantes, par exemple dans le traitement ou la prévention de maladies faisant l'objet de traitements au moyen d'inhibiteurs de déformylase peptidyle, tels que le traitement des maladies bactériennes.

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