Pyrrolidine-containing monomers and oligomers

Details Pyrrolidine-containing monomers and oligomers Pyrrolidine-containing monomers and oligomers

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) C07D 207/12 (2006.01) C07D 207/337 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/06 (2006.01) C07D 413/06 (2006.01) C07D 417/12 (2006.01) C07D 473/34 (2006.01) C07D 521/00 (2006.01) C07F 9/572 (2006.01)

Patent

CA 2180978

Novel pyrrolidine monomers bearing various functional groups are used to prepare oligomeric structures. The pyrrolidine monomers can be joined via standard phosphate linkages including phosphodiester, phosphorothioate, and phosphoramidate linkages. Useful functional groups include nucleobases as well as polar groups, hydrophobic groups, ionic groups, aromatic groups and/or groups that participate in hydrogen-bonding,

De nouveaux monomères de pyrrolidine contenant divers groupes fonctionnels sont utilisés pour produire des structures oligomériques. Les monomères de pyrrolidine peuvent être liés par des liaisons phosphate standard comprenant des liaisons phosphodiester, phosphorothioate et phosphoramidate. Les groupes fonctionnels pouvant être utilisés comprennent les bases nucléiques ainsi que les groupes polaires, hydrophobes, ioniques, aromatiques et/ou des groupes participant à la liaison de l'hydrogène.

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