C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 207/09 (2006.01) A61K 31/40 (2006.01) A61K 31/44 (2006.01) C07D 207/00 (2006.01) C07D 213/00 (2006.01) C07D 295/00 (2006.01) C07D 295/04 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2234134
A pyrrolidine derivative or a salt thereof expressed by the following formula 1: (see fig. I) wherein R1 is an alkenyl group; R2 is a lower alkoxy group or a halogen atom; R3 is a lower alkyl group; X is a group expressed by -O- or -S-; Y is carbon or nitrogen atom; m is an integer of 1 to 3; and n is an integer of 0 to 2. The pyrrolindine derivative has an anti-ulcer effect or an antibacterial activity against Helicobacter pyroli, and has also high safety to be available for prevention or cure of ulcers.
Dérivé de la pyrrolidine ou sel de ce composé, exprimés par la formule suivante 1 (voir fig. I), où R1 est un groupe alcényle, R2 est un groupe alcoxy inférieur ou un atome d'halogène, R3 est un groupe alkyle inférieur, X représente -O- ou -S-, Y est un atome de carbone ou d'azote, m est un entier de 1 à 3, enfin n est un entier de 0 à 2. Le dérivé de la pyrrolidine a des propriétés antiulcéreuses ou une activité antibactérienne vis-à-vis d'Helicobacter pyroli; il permet également de prévenir ou de traiter de façon très sécuritaire les ulcères.
Nishino Chikao
Uetake Tomohiro
Gowling Lafleur Henderson Llp
Shiseido Co. Ltd.
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