Pyrrolidine derivatives

Details Pyrrolidine derivatives Pyrrolidine derivatives

C - Chemistry, Metallurgy

07

D

167/233, 260/323

C07D 207/14 (2006.01) C07D 207/12 (2006.01) C07D 207/16 (2006.01) C07D 409/12 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1329391

ABSTRACT There are described compounds of the formula: Image wherein R1 is hydrogen or an acyl group, R2 is an acyl group, R3 is carboxy(lower)alkyl, lower alkyl substituted with carboxy and one or more halogen atom(s), protected carboxy(lower)alkyl, carboxyaryl, protected carboxyaryl, carboxy, protected carboxy, hydroxy(lower)- alkyl, sulfino(lower)alkyl, phoephono(lower)alkyl, protected phosphono(lower)alkyl or halo(lower)- alkyl, R7 is hydrogen or lower alkyl, and A is Image or Image (in which R8 is hydrogen or lower alkyl), and a pharmaceutically acceptable salt thereof. Compositions containing same as well as processes for their preparation are also described. The compounds are useful as therapeutic agents for diseases such as thrombosis, asthma, nephritis or the like.

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