Pyrrolidine derivatives

Details Pyrrolidine derivatives Pyrrolidine derivatives

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/402 (2006.01) A61K 31/4439 (2006.01) A61K 31/497 (2006.01) A61K 31/501 (2006.01) A61K 31/506 (2006.01) C07D 207/12 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2415681

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, X1, X2, X3, X4 and Y are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

La présente invention concerne des composés correspondant à la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, X?1¿, X?2¿, X?3¿, X?4¿ et Y correspondent à la définition donnée dans la description et dans les revendications. L'invention concerne également des formes dimères et/ou des esters et/ou des sels pharmaceutiquement acceptables de ces composés. Les composés selon l'invention peuvent être utilisés comme inhibiteurs des métalloprotéases, par exemple des zinc protéases, en particulier des zinc hydrolases, et sont efficaces dans le traitement d'états pathologiques associés à la vasoconstriction, lesquels sont de plus en plus fréquents.

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