Pyrrolidine derivatives and process for preparing the same

C - Chemistry – Metallurgy – 07 – D

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C07D 495/08 (2006.01) C07D 207/16 (2006.01) C07D 401/02 (2006.01) C07D 403/02 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07F 7/10 (2006.01)

Patent

CA 2086649

ABSTRACT PYRROLIDINE DERIVATIVES AND PROCESS FOR PREPARING THE SAME Pyrrolidine derivatives of the formula (1): Image (1) wherein R is a protective group of the amino group, intermediates for constructing the 2-positioned side chain of antibacterial penem and carbapenem compounds, are prepared by allowing Image to react with active esterifying agents in the presence of a base, further allowing the product to react with hydrogen sulfide in the presence of a base and then treating the product with a base.

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