Pyrrolidine derivatives as erk inhibitors

Details Pyrrolidine derivatives as erk inhibitors Pyrrolidine derivatives as erk inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/16 (2006.01) A61K 31/4025 (2006.01) A61P 35/00 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01) C07D 487/08 (2006.01)

Patent

CA 2642762

Disclosed are the ERK inhibitors of Formula (1.0): and the pharmaceutically acceptable salts and solvates thereof. Q is a piperidine or piperazine ring that can have a bridge or a fused ring. The piperidine ring can have a double bond in the ring. All other substitutents are as defined herein. Also disclosed are methods of treating cancer using the compounds of Formula (1.0).

L'invention concerne des inhibiteurs ERK de formule (1.0) : et leurs sels et solvatations pharmaceutiquement acceptables. Q est un anneau pipéridine ou pipérazine qui peut avoir un pont ou un anneau fusionné. L'anneau pipéridine peut avoir une double liaison dans l'anneau. Tous les autres substituants sont comme définis dans la présente. L'invention concerne aussi des méthodes de traitement d'un cancer utilisant des composés de formule (1.0).

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